Carcinoembryonic Antigen (CEA)

Carcinoembryonic antigen (CEA) is a glycoprotein that is normally produced by the fetus and secreted by gastrointestinal cells. In adults, it is normally found in trace amounts.

Test Description

Carcinoembryonic antigen (CEA) is a glycoprotein that is normally produced by the fetus and secreted by gastrointestinal cells. In adults, it is normally found in trace amounts. However, CEA tends to increase in the case of malignancies. It is primarily nonspecific and thus is not used alone in cancer diagnosis. This test has been found to be effective in the early detection of colorectal cancer, with CEA levels rising several months before clinical symptoms appear. Smaller tumors found early in development will have low or normal CEA levels, whereas advanced or metastatic conditions are likely to have higher CEA levels. Measurement of CEA levels can also be helpful monitoring the response of the patient to cancer treatment, and for monitoring the patient for recurrence of cancer.
 
Carcinoembryonic Antigen (CEA)

THE EVIDENCE FOR PRACTICE

  • Drawing a CEA level has been recommended before and every 3 months for the first
  • 2 years after resection of colorectal cancer.
  • Postoperative return to normal of an elevated preoperative CEA is associated with complete tumor resection, whereas persistently elevated values indicate the presence of residual disease.
  • Elevated preoperative CEA levels have been found to be an independent predictor
  • of poor outcome.

Normal Values

  • Nonsmoker: <3 ng/mL (<3 mcg/L SI units)
  • Smoker: <5 ng/mL (<5 mcg/L SI units)

Possible Meanings of Abnormal Values

Increased

  • Acute pancreatitis
  • Acute renal failure
  • Bacterial pneumonia
  • Breast cancer
  • Cholecystitis
  • Chronic obstructive pulmonary disease
  • Cirrhosis
  • Colorectal cancer
  • Crohn’s disease
  • Diverticulitis
  • Hypothyroidism
  • Leukemia
  • Lung cancer
  • Neuroblastoma
  • Ovarian cancer
  • Pancreatic cancer
  • Peptic ulcer disease
  • Pulmonary emphysema
  • Radiation therapy
  • Smoking
  • Ulcerative colitis

Contributing Factors to Abnormal Values

  • Smoking may increase CEA levels.
  • Drugs that may increase CEA levels: antineoplastic agents, hepatotoxic drugs.

Interventions/Implications

Pretest

  • Explain to the patient the purpose of the test and the need for a blood sample to be drawn.
  • No fasting is required before the test.

Procedure

  • A 5-mL blood sample is collected in an EDTA (lavender-top) tube.
  • Gloves are worn throughout the procedure.

Posttest

  • Apply pressure at venipuncture site. Apply dressing, periodically assessing for continued bleeding.
  • The sample is labeled and transported to the laboratory.
  • Report abnormal results to the primary care provider.

Clinical Alerts

When cancer metastasizes to other organs, CEA levels rise and may be present in other body fluids, such as cerebrospinal fluid.

COMMENTS

Name

Articles for Dentists,5,Articles for Vets,18,Biochemistry Articles,11,Fish Diseases,4,Oral Health and Herbal Medicine,2,Poultry Diseases,6,Test Information,11,
ltr
item
Dr Lobby | DrLobby.com: Carcinoembryonic Antigen (CEA)
Carcinoembryonic Antigen (CEA)
Carcinoembryonic antigen (CEA) is a glycoprotein that is normally produced by the fetus and secreted by gastrointestinal cells. In adults, it is normally found in trace amounts.
https://1.bp.blogspot.com/-lZffCXHpRco/Xt4W6Jh2KrI/AAAAAAAAAMs/j0S48trqpfIJ8ecWmYZpr_q8EBZFcnTRgCK4BGAsYHg/w400-h238/CEA.jpg
https://1.bp.blogspot.com/-lZffCXHpRco/Xt4W6Jh2KrI/AAAAAAAAAMs/j0S48trqpfIJ8ecWmYZpr_q8EBZFcnTRgCK4BGAsYHg/s72-w400-c-h238/CEA.jpg
Dr Lobby | DrLobby.com
https://www.drlobby.com/2019/07/carcinoembryonic-antigen-cea.html
https://www.drlobby.com/
https://www.drlobby.com/
https://www.drlobby.com/2019/07/carcinoembryonic-antigen-cea.html
true
8312107627841756316
UTF-8
Loaded All Posts Not found any posts VIEW ALL Readmore Reply Cancel reply Delete By Home PAGES POSTS View All RECOMMENDED FOR YOU LABEL ARCHIVE SEARCH ALL POSTS Not found any post match with your request Back Home Sunday Monday Tuesday Wednesday Thursday Friday Saturday Sun Mon Tue Wed Thu Fri Sat January February March April May June July August September October November December Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec just now 1 minute ago $$1$$ minutes ago 1 hour ago $$1$$ hours ago Yesterday $$1$$ days ago $$1$$ weeks ago more than 5 weeks ago Followers Follow THIS PREMIUM CONTENT IS LOCKED STEP 1: Share to a social network STEP 2: Click the link on your social network Copy All Code Select All Code All codes were copied to your clipboard Can not copy the codes / texts, please press [CTRL]+[C] (or CMD+C with Mac) to copy Table of Content